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Advances in bioinformatics and systems biology facilitate the mapping of intricate protein-protein interactions, the identification of potential biomarkers, and the clarification of molecular mechanisms underlying AD progression

Experimental studies have utilized diverse animal models including transgenic mice (APP/PS1, 5FAD), senescence-accelerated mice (SAMP8), and even Drosophila melanogaster to explore these mechanisms

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Xu Z, Li S, Li K, Wang X, Li X, An M, et al