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Surgical intervention : When conservative measures fail, surgical repair (such as Achilles tendon repair, rotator cuff repair, or ACL reconstruction) provides well-studied, reliable outcomes

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Still, researchers should know a few things: Mild Side Effects : Some users report minor, short-lived effects

It causes a transient rise in systolic blood pressure ($+6$ mmHg) and a slight drop in heart rate that lasts about 12 hours

Constipation on tirzepatide is most common during the initial titration phase and following dose escalations, with many patients experiencing improvement within several weeks as the body adapts

J Pharmacol Exp Ther 206(1):227232 Di Stefano A, Sozio P, Cerasa LS (2008) Antiparkinson prodrugs