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Thus, our study reveals that endometrial stromal cell ferroptosis in the ovarian endometrioma may trigger cytokine secretion and promote angiogenesis of adjacent lesions via paracrine actions to drive the development of endometriosis, providing a rationale for translation into clinical practice and developing drugs for endometriosis

Luteolins therapeutic potential is further constrained by fundamental biopharmaceutical limitations, including poor aqueous solubility, low membrane permeability, and extensive phase II metabolism, all of which restrict its oral bioavailability (Wang et al., 2024)

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Another example of a disruptor protein is SQSTSM1/p62, which is a polyubiquitin binding protein and targets various substrates for autophagy (Lu et al., 2001

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