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These limitations reflect both the shortcomings of this review constrained by existing evidence, and the urgent core scientific questions and unmet clinical needs in the toxicology and clinical application of platinum-based agents

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The importance of iron homeostasis is evident as the iron chelator deferoxamine effectively suppresses ferroptosis induced by intracellular iron overload (Costa et al., 2023)

& Hoshida, Y

Acknowledgements We are grateful to G

GH-secretagogues are plausible but unproven for fitness, with real metabolic and safety questions