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Considering that dysregulation of the Wnt/-catenin pathway has been reported in many neurodegenerative diseases, the LRP6 is a promising therapeutic target in other neurodegenerative diseases ( On the other hand, damaged BECs accelerate the A deposition and precede the progress of AD

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Strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs (grant P40 OD010440)