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In addition, some quinone compounds, such as -LAPachone and aloin, have similar effects on heart protection [182, 183]

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Excess bile, a heme byproduct, can form gallstones, block bile flow, damage the liver and bile ducts, and raise GGT and ROS levels

This may explain why p21 overexpression alone was not sufficient to fully inhibit ferroptosis in our hands: p53 stabilization is needed together with p21 induction for complete inhibition of RNR complex expression and function