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79 Furthermore, adalimumab is a tumor necrosis factor (TNF) inhibitor, and a rheumatoid arthritis patient on this medication demonstrated hair repigmentation

In the CNS it induces hypothalamic gliosis and lipid accumulation, which may disrupt appetite and energy regulation [67]

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These effects depend on factors such as melatonin receptors, local hormone concentration, type of cellular receptors, and signaling systems [3], according to the phase of the circadian cycle