Bardon, Ceder, and Kollberg were the first to demonstrate significantly increased activities of glycolytic enzymes such as hexokinase (HK), phosphofructokinase-1 (PFK1), pyruvate kinase (PKM) and lactate dehydrogenase (LDH) in activated fibroblasts from cystic fibrosis patients (204)
doi: 10.1016/j.forsciint.2011.10.024 82 SulekKHanT-LVillas-BoasSGWishartDSSohS-EKwekKet al
30 No significant side effects were reported in any of these studies
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American Journal of Surgery
Interestingly, amplification of wild-type MYC was also observed in two of these patients, CAS-D and CAS-B, providing a mutational combination proposed to facilitate tetraploidization 46