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[iii] In vitro models, including human cells and tissues, may supplement the information regarding a drugs potential effect on humans

Semaglutide is the most extensively studied GLP-1 receptor agonist a single, highly selective incretin-pathway agonist that has become the reference standard against which newer dual and triple agonists are measured

PMID 38823477

Liraglutide (Saxenda) and semaglutide (Wegovy), both GLP-1 receptor agonists, can cause modest increases in resting heart rate (typically a mean rise of approximately 24 beats per minute, though some individuals may experience larger increases)

The primary analysis of the results found that the incidence of adverse neonatal outcomes was significantly lower in the immediate-treatment group compared to the control group (adjusted risk difference, -5.6 percentage points

Moreover, all included studies were RCTs