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For many women, the body reacts to this constant irritation by tightening the throat musclesleading to that persistent 'lump in the throat' (globus sensation) that doesn't go away with water or food

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The active ingredients (semaglutide, tirzepatide) are FDA-approved drugs, but compounded preparations are legally permissible for patient-specific use under physician supervision

The article attributes it to estrogen decline, which reduces insulin sensitivity, slows resting metabolic rate, and shifts fat distribution toward the abdomen

Missing doses weakens appetite suppression during that week and can increase hunger and side effects like nausea when you resume, so setting phone reminders helps maintain consistency

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