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Comparators for third-line treatment consisted of canagliflozin 300 mg, empagliflozin 25 mg, dapagliflozin 10 mg, and sitagliptin 100 mg

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Studies investigating the effects of exenatide treatment in NOD mice reported a modest effect on diabetes incidence (18, 20)

mechanical stress can render the peptide biologically inactive

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13.2 Animal Toxicology and/or Pharmacology Increase in lactate levels and decrease in glucose levels in the plasma and cerebrospinal fluid (CSF) were observed in mechanistic studies with SNAC in rats