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Berberich AJ, Hegele RA

Simultaneously, semaglutide suppresses inappropriate glucagon secretion from pancreatic alpha cells, further contributing to improved glycemic control

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Most people follow a stepwise increase every four weeks: Weeks 14: 1 mg once weekly Weeks 58: 2 mg once weekly Weeks 912: 4 mg once weekly Weeks 1316: 8 mg once weekly Weeks 17 and beyond: Up to 12 mg once weekly Your highest dose depends on your comfort, response, and providers recommendation

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These timeframes are anchored to the trial titration schedule and should be interpreted with caution, as real-world variability may be considerable