Interestingly, tirzepatide, a dual-acting GIP/GLP-1 receptor agonist that is now clinically approved for both obesity and T2D, was designed with an amino acid sequence closely resembling that of native GIP, resulting in strong preference for GIPR binding over the GLP-1R
Consistent with this observation, the combination of olmesartan and exenatide has been shown to attenuate the renal NADPH oxidase 4 (Nox4) expression in insulin-resistant Otsuka Long-Evans Tokushima Fatty (OLETF) rats (Rodriguez et al., 2020)
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GLP-1 drugs surge in popularity for treating obesity The backstory: GLP-1 drugs have surged in popularity in recent years for their effectiveness in treating obesity and diabetes
In preclinical models it is studied for its effect on appetite signalling, energy expenditure and fat-mass reduction, which is why physique and weight-management researchers track it so closely
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