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Pivotal trial result: AOD-9604's Phase 2b trial (536 subjects, 24 weeks) failed its primary endpoint
AMBRA1-mediated Mitophagy counteracts oxidative stress and apoptosis induced by neurotoxicity in human neuroblastoma SH-SY5Y cells
Pote, S
Extrapolating from semaglutide and tirzepatide data is reasonable given shared molecular characteristics (large protein-based structures, poor oral bioavailability), but it is not the same as having direct evidence
Three doses per week can theoretically maintain adequate levels
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