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Van den Heuvel, Vitamin B(12) in Relation to Oxidative Stress: A Systematic Review, Nutrients , vol

Hierarchical clustering of commonly engaged proteins by the fold increase in target engagement in senescent versus non-senescent conditions (referred to as senescence selectivity) identified broadly highly-reactive proteins, clusters of proteins with specificity to certain chemotypes and others (such as GPX4) that were enriched in probes related to three different SCLAs (Fig

this is not a failure of the compound but a predictable biological response to significant fat reduction