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At the time, it was very difficult to measure oxyntomodulin specifically, because of the inherent cross-reaction that any antibody against oxyntomodulin would have with either glucagon or glicentin, but via chromatographic studies of extractable and circulating oxyntomodulin (40), combined with studies of its potency with respect to insulin secretion, it was eventually considered unlikely that this peptide was the putative second incretin hormone, a concept that still prevails (41)