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In a cohort of 37 children with cavitating leukoencephalopathies, three (3/37, 8.1%) were compound heterozygotes for pathogenic mutations in the NDUFV2 gene [109]

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Effects on cardiovascular morbidity and mortality In total, 33, 37 and seven RCTs reported information on (externally adjudicated) major adverse cardiovascular events (MACE), cardiovascular mortality and hospitalization due to heart failure (HHF), respectively (Supplementary Figs

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Laggiunta di cagrilintide non sembra aumentare significativamente gli effetti collaterali rispetto a semaglutide ad alte dosi, ma sono necessari studi di confronto diretto per confermare questo aspetto