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Epigenetic matters: the link between early nutrition, microbiome, and long-term health development

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BJP-IVb prevents PD by inhibiting iron regulatory protein (IRP2) from iron overload-mediated ferroptosis in dopaminergic neurons, as demonstrated by diminished lipid peroxidation and reduced iron content

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Chronic exposure to oxidative stimuli, for instance, can induce a senescent phenotype characterised by impaired regenerative capacity and diminished differentiation potential, ultimately compromising tissue integrity and repair mechanisms [136]