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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

S., Viswanath, B., & Rajagopal, S

Kidney Function Decline Long-term dehydration from GI side effects may strain kidney function over time

Newsome, P

Ookhtens M, Mittur AV, Erhart NA: Changes in plasma glutathione concentrations, turnover, and disposal in developing rats

For this reason, populations with high NTHi carriage rates experience the highest OM disease burden (Sun et al., 2012