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The main neurocognitive disorders in NDD (AD, PD, etc.), conditions related to alcohol and substance abuse, stroke, traumatic brain injury, and depressive disorders are the closest therapeutic targets
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By contrast, we did observe a significant decrease in serum levels of D-serine, a co-agonist of the glycine site of the NMDA receptor [5], [42] (Table 2), which is consistent with previous reports [6], [10]
Lack of critical involvement of caspase-3 in eryptosis has been emphasized in an extensive analysis of the caspase-3 contribution to eryptosis, which has revealed that eryptosis triggered in vitro by diverse compounds is not associated with caspase-3 recruitment in the majority of cases [84]