Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) binds at the AT 1 receptor subtype and mediates systemic blood pressure, body water/electrolyte balance and influences cerebral blood flow, cerebroprotection, seizure, stress and depression
Several signaling pathways have been implicated in both mitochondrial biogenesis and mitophagy, and they may play important roles in coordinating these processes (Figure 2)
It helps protect cells by neutralizing free radicals, thereby decreasing oxidative stress
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