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No hepatic safety signal has been identified, a finding of particular importance given the hepatotoxicity that led to the discontinuation of competing oral GLP-1 programs

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It also helps regulate the immune response

Encouraged to aim for metoprolol dose of at least 100mg or bisoprolol dose of at least 5mg Primary endpoint: Composite of death from any cause or new myocardial infarction Secondary endpoints: death from any cause death from cardiovascular causes myocardial infarction hospitalization for atrial fibrillation hospitalization for heart failure Results: Population: Median age: 65 years 22.5% of the patients were women 35.2% had an ST-segment elevation myocardial infarction Beta-blocker group: 2508 patients w 1560 (62.2%) treated with metoprolol 948 (37.8%) treated with bisoprolol Median follow-up: 3.5 years (interquartile range, 2.2 to 4.7) in each trial group