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Gene Expression: The 4,000-Gene Observation Perhaps the most striking claim in the GHK Cu literature comes from genomic studies by Pickart and Margolina, who reported that GHK Cu can modulate the expression of over 4,000 human genes approximately one-sixth of the human genome

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The expression levels for each of the genes were normalized to fragments per kilobase of exon model per million mapped reads (FPKM) using a software package called RSEM 79