Compelling evidence from landmark clinical trials, particularly STEP-HFpEF, STEP-HFpEF DM and SUMMIT, has established the efficacy of GLP-1RAs in improving HF-related symptoms and quality of life, as well as reducing worsening HF events, in the prevalent phenotype of HFpEF in the setting of obesity and T2D
More recent outcomes data suggests potential reductions in major adverse cardiovascular events among high-risk populations, further broadening interest in the downstream health implications of sustained GLP-1 drug use
doi: 10.1093/cvr/cvaa324 57 D'AlessioSUngaroFNovielloDLovisaSPeyrin-BirouletLDaneseS
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Diabetes 53 , 654662 (2004)
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