doi: 10.1056/NEJM198408093110604 127 LauritzenTFrost-LarsenKLarsenH-WDeckertT
This can lead to a temporary, and we stress temporary , suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland
A recurring theme across non-incretin metabolic peptides is that early development efforts were constrained by pleiotropy, cardiovascular effects, or incomplete receptor characterization rather than by lack of metabolic relevance
If the research question is weight loss alone, pushing toward the maximum tolerated dose seems logical, since the relationship between dosing and body fat reduction remains strong
You should definitely speak with your GP if: You have been diagnosed with type 2 diabetes or non-diabetic hyperglycaemia (pre-diabetes) and are considering supplements as an alternative or addition to prescribed treatment You are currently taking medications for diabetes, as supplements may interact and alter blood glucose control You are taking any prescribed medications, particularly anticoagulants, immunosuppressants, or medications with narrow therapeutic windows You are experiencing symptoms of poor glucose control, such as excessive thirst, frequent urination, unexplained weight loss, or fatigue You are interested in pharmaceutical GLP-1 or GIP receptor agonists for diabetes management or weight loss Seek urgent medical help via NHS 111 or 999 if you experience: Severe dehydration Abdominal pain with vomiting Deep or rapid breathing Confusion or drowsiness These could indicate a serious hyperglycaemic emergency requiring immediate treatment
This postulation was later confirmed in a mouse model, where stimulation of GLP-1 receptors on atrial cells induced a chronotropic effect, but only when neuronal input was present (112)
