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Dehydration concentrates urine and promotes crystal formation, increasing kidney stone risk in susceptible individuals

2) Diarrhea with mucus (infection or irritation) When stool moves too fast, the bowel lining can get irritated and produce extra mucus

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The essential nature of GPX4 is demonstrated by the fact that genetic disruption of the entire Gpx4 gene in homozygous Gpx4 knockout causes in utero fetal death by midgestation (Imai et al., 2003)