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Topical reactions: rare irritation , redness or dryness , especially at 3 %+ percentages on sensitive skin

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Storage & Handling Store refrigerated (28 C), dry and protected from light

In hyperuricemia, uric acid is supersaturated in urine and forms uric acid crystals, which are transported to lysosomes by the endocytosis of renal tubular epithelial cells, destroying the lysosomal membrane and causing lysosomal rupture, in turn, resulting in renal inflammation 20

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Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells