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Br J Cancer 96(12):17881795 Carmeliet P, Jain RK (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

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It has been proved that blocking the biological axis of CXC chemokine/CXCR2 can reduce the risk of malignant tumors ( + /H + exchanger regulatory factor-1 (NHERF1) form macromolecular complexes on the plasma membrane of pancreatic cancer cells, which functionally couples the signal cascade mediated by CXC chemokine and PLC-3 ( in vitro and in vivo ( Pancreatic intraepithelial neoplasia (PanIN) is considered to be the precursor of pancreatic cancer

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