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73 Studies 74 have shown that TNF- can amplify local inflammation by activating the NLRP3 inflammasome and inducing IL-1 secretion, while also binding to TNF-R1 on esophageal sensory neurons and activating the p38 MAPK pathway, thereby increasing the open probability of TRPA1 channels and enhancing mucosal sensitivity to refluxate
doi:10.1038/nature04568
Diminishing food noise is actually one of the biggest draws of GLP-1 medications
The National Institutes of Health, whose Intramural Research Program partly funded the trial, described the findings as evidence that GLP-1 medications could help treat alcohol use disorder
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Carneiro, H
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