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Evidence from Clinical Trials Clinical trials investigating the efficacy of GLP-1 agonists have revealed promising results

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We changed pharmacy vendor, now you cant get it unless you have had a history of diabetes. Senior Benefits Manager, large manufacturer Weve never offered it for weight loss, and it is still one of our top three prescriptions spends every year. HR Professional, large manufacturer We dont allow GLP-1s for weight loss In our type 2 diabetes population, 50% are utilizing the GLP-1s, so we are now excluding them for anything except type 2 diabetes [to manage costs]. Director of Benefits, large manufacturer The future of GLP-1 drug prices Employers are also recognizing that the price paid by employers for GLP-1 drugs are sometimes higher than online direct-to-consumer prices reflecting manufacturer discounts

A patient with obesity taking retatrutide for 68 weeks doesn't just lose 71 poundsthey reduce their 10-year risk of heart attack and stroke by an estimated 35-40% based on improved risk factors alone

Circ Res (2015) 116:11626

If you're seeing two or more of these, reduce training volume by 3040% for two weeks before making any other changes