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The increase in liver size (liver:body weight ratio) could be explained by the increase in circulating GH as a result of the lack of the IGF-1-mediated negative feedback mechanism, where circulating IGF-1 produced by the liver can regulate secretion of GH and consequently the size of the liver (164, 309311)

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Glutathione-depleting nanomedicines for synergistic cancer therapy

doi: 10.1016/j.neuroscience.2013.04.017 210 LiWWPenderisJZhaoCSchumacherMFranklinRJ