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Tirzepatide has a shorter half-life of about five days, according to the Zepbound label

doi: 10.1038/nm.3128

This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)

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Similarly, a high-fat diet has been shown to induce dysbiosis in gut microbiota, subsequently leading to reduced expression of mucus and tight junction proteins in the colon, triggering local and systemic inflammation [109, 110]

How are GLP-1 receptor agonists administered