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High-dose oral therapy (typically 1,000 micrograms daily) relies partly on passive diffusion and can be effective even in many people with malabsorption issues, according to UK guidance

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All candidates require a thorough medical evaluation, with careful screening for renal failure, hepatic insufficiency, or cardiopulmonary compromise, and close monitoring whenever glycine is administered to anyone with borderline organ function

Inducing on purpose a PEM (266, 310) with potentially severe consequences is ethically questionable unless appropriate precautions are taken, which is feasible (311)

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