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The serum GSH level, which serves as an antioxidant agent excessively consumed in oxidative stress injury, was significantly enhanced by APP treatment time-dependently (Fig

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Arora A, Hakim I, Baxter J, Rathnasingham R, Srinivasan R, Fletcher DA, et al

Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation (32)