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Link below outlines UK treatment patterns for people with B12 deficiency aged 16 onwards cks.nice.org.uk/topics/anae

PubMed reference (NNMT inhibition & metabolic health)

We then simulated payment for the remaining claim lines as if they were paid at the PFS-equivalent rate, removing a portion of the payment associated with rural Sole Community Hospitals based on our finalized exception for those hospitals

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Because its a water-soluble vitamin, any excess that isnt used should be flushed from the body and not pose too much risk (not the case with fat-soluble vitamins like vitamin A)

Pathway map of NNMT and NAD salvage in adipocytes, highlighting nicotinamide NAMPT NMN NAD and the competing NNMT branch to 1-MNA