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Regarding potential confounding by indication related to an obesity diagnosis, the number of outcomes in individuals diagnosed with obesity according to the registers is too low to carry out a meaningful subgroup analysis

In parallel, the landscape of pharmacological therapies for T2DM and (to a lesser extent) obesity has expanded in recent decades with new classes of molecules coming into the market

Body composition changes also differ

In recent years, a variety of mechanisms for the beneficial effects of GLP-1RAs on the brain have been discovered, including the reduction of neuroinflammation and increase of signal transduction in surviving cells

The ERK and JNK are parts of the insulin signal pathway and closely associated with tau hyperphosphorylation

Whatever the employer contributes goes directly toward the cost of the medication