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Subramanian and Rusch describe in a letter in Movement Disorders why weight loss in Parkinson's disease remains under-recognized and why monitoring nutrition should become a routine part of care

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Elevated ATF3 expression in aging osteocytes promotes iron uptake by upregulating TFR1 while inhibiting SLC7A11-mediated cystine uptake, leading to iron overload and lipid peroxidation, ultimately resulting in ferroptosis

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Add regular resistance training and monitor progress at four to six week intervals