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The pKM260::OsDHAR plasmid was used as a template for site-directed mutagenesis to introduce the K8A, C20A, C20S and K47A point mutations into the OsDHAR gene

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226 PPAR agonists, such as the thiazolidinediones, rosiglitazone and pioglitazone, have been shown to reduce lung inflammation in mouse models of tobacco smoke, and studies have found that treating model mice with thiazolidinedione can reverse emphysema