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Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

The observed congestion was minimal, and there was no evidence of fatty degeneration, necrosis, or invasion of mononuclear cells

doi: 10.1016/0925-4439(95)00091-7 331 Hope-RossMMahonGJJohnstonPB

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