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Patients who weighed 250 lb at baseline and lost about 56 lb after 60 weeks of maintenance-dose tirzepatide treatment may regain weight to around 235 lb after discontinuation (worst observation carried forward analysis), despite access to rescue tirzepatide after week 84 for those who regained at least 50% of lost body weight
PlexusDx patients often remain on tirzepatide for 12 to 36 months, though some continue indefinitely depending on their response, health status, and personal preference
Semaglutide is a GLP-1 only, while tirzepatide is a dual agonist with another natural hormone called GIP
Park, I
Putting It Together Running on semaglutide works best when you adjust expectations in the short term, protect your lean mass with resistance training, fuel deliberately even when appetite is suppressed, and give your body time to adapt to the new metabolic reality
Tirzepatide sold as Mounjaro for type 2 diabetes and Zepbound for weight management became the worlds best-selling drug in 2025 with combined global sales of $36.5 billion
