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TRT (Testosterone Replacement Therapy) for Hypogonadism R: Critical differences: hCG Intratesticular testosterone: maintained (spermatogenesis preserved) Testicular volume: preserved Fertility: maintained/restorable Frequency: 2-3x/week Cost: higher TRT Intratesticular testosterone: suppressed (atrophy, infertility) Testicular volume: reduced 30-50% Fertility: compromised Frequency: variable (daily-weekly depending on formulation) Cost: lower Choice: hCG if fertility/testicular function is important

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The compound has been studied across multiple research streams covering its mechanism, biological-activity profile, and translational-research framings

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In 2025, that threshold is approximately $187 million