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407 GLP-1 inhibits glucose uptake in astrocytes and promotes beta-oxidation, which is essential for regulating energy balance in the brain and maintaining mitochondrial integrity

Kiesewetter DO, Guo N, Guo J, Gao H, Zhu L, Ma Y, Niu G, Chen X

Approved by the FDA for type 2 diabetes management (as Ozempic and Rybelsus) and chronic weight management (as Wegovy), semaglutide represents a significant advancement in GLP-1-based therapeutics

Its kind of hard to lose weight when you get older, says the 62-year-old in one of the clips

The treatment of type 2 diabetes requires positive modulation of GLP-1R to inhibit glucagon secretion and stimulate insulin secretion in a glucose-dependent manner 2

Menopause, sleep disruption, vasomotor symptoms, insulin resistance, body-composition changes, thyroid dysfunction, low testosterone, and chronic stress signaling can all influence how patients feel, recover, move, sleep, and maintain metabolic health