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doi:10.3748/wjg.v23.i31.5669

Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors

Kettenmann, H

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First we assessed proteolytically active proteasome subunits MECL1 , LMP2 and LMP7 required for assembly of the 20 S proteasome, protein degradation and amino acid recycling 25 , finding IGF-induced MECL1 downregulation in DU145 cells only and LMP2 downregulation in both DU145 and 22RV1 (Supplementary Figure S2A)