The answer starts with observations made by Bayliss and Starling in 1902--the duo ground up intestinal tissue, and administered these crude extracts to animals
GLP-1 diet
Relationship of psoriasis severity to obesity using same-gender siblings as controls for obesity
That's the whole routine

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Final thoughts from the online health coach There are risks associated with this medication and challenges to overcome when using it, but they are in most cases better than long term obesity