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Natural active ingredients, such as polyphenols, peptides, polysaccharides, flavonoids and alkaloids, show multifaceted beneficial effects in DKD treatment by acting on core targets and signaling pathways, such as MAPK, Nrf2/Keap1, NF-B, including antioxidant, regulation of glycolipid metabolism, promotion of cellular autophagy, and inhibition of inflammatory response, which can improve renal function and alleviate renal pathologic In addition, we believe that in future research, we can further study how to improve the bioavailability of active substances, and at the same time, we can increase the technology of nanocarriers, liposomes, gene editing, etc
Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, Rajbhandari P, Stokes ME, Bender HG, Csuka JM, et al
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This metabolic speed-up often leads to the breakdown of structural proteins
