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Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]
At week 12, there were no significant differences found between the treatment and placebo groups in terms of the total number of UV spots, spot polarization, or measurements of skin tone
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doi: 10.1016/s0140-6736(21)01443-4 33
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