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Stopping abruptly may cause rebound appetite and weight regain

These may not yet have achieved an equivalent scale of impact compared to GLP-1s, but some have not been tried at scale or with the intensity that is required, but may offer more cost-effective, long lasting or equitable solutions [11]

McKee KK, Palyha OC, Feighner SD, et al

Over time, this leads to consistent, sustainable fat loss without the intense restrictions of crash diets

There is a strong relation between variants in the gene encoding the melanocortin-1 receptor (MC1R) and ephelides in childhood suggesting the MC1R gene is the major ephelide gene [5]

One primary advantage is the peptides rapid absorption through the nasal mucosa, which the peptide to enter the bloodstream without going through the digestive system which may result in quicker outcomes