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Evidence from the pre- and postpartum periods was considered to avoid controversy raised by consideration of only limited evidence of risks during the prepartum period

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Its decline with aging represents a key mechanistic link between circadian disruption and downstream metabolic and oxidative consequences, as discussed in the following section

10 The growing prevalence and burden of GI disorders highlight the urgent need for effective, safe, and sustainable treatment approaches

These oxidation products enhance the catabolism of retinoic acid by inducing the activity of the cytochrome P450 enzyme