In response to oxidative stress, p62 activates NRF2 by directly binding to its ubiquitin ligase partner KEAP1 during the oxidative stress response
SAM-e is an amino acid that is naturally produced by the body
High-purity lots limit background signals in assays
measured B12 levels in 51 mothers, placentas, and infants post-delivery, and found that the intervillous space in the placenta contained a higher concentration of B12 (796 pmol/l) than the blood of the mothers (590 pmol/l) or their newborns (252 pmol/l)
doi: 10.3389/fneur.2021.775781 97 WangX.MaR.LiuX.ZhangY
The form, dose, and timing are worth recording, and further workup becomes necessary if the elevation persists once those sources are accounted for, or if symptoms, examination findings, or other labs raise concern