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Even if youre using vitamin B12 to help you lose weight, it is best not to overdo it as there are side effects of upping the dosage

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Studies demonstrate that NNMT inhibition "enhances fasting blood glucose levels, glucose tolerance, and insulin sensitivity" while reducing triglycerides and decreasing lipid deposition

In vitamin B 12 deficiency, the mutase reaction is impaired, causing accumulation of D-methylmalonyl-CoA, which is converted to methylmalonic acid

By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed

As the GLP-1 receptors become activated, it triggers a few responses